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apt [2017-8-11 16:0:3]
adenine phosphoribosyltransferase, universally conserved protein
function
purine salvage and interconversion
product
adenine phosphoribosyltransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.3|Purine salvage and interconversion][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]Gene
Coordinates
2,822,901 → 2,823,413
The protein
Catalyzed reaction/ biological activity
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)Protein family
purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)Modification
phosphorylated on Arg-85 [Pubmed|22517742]Structure
[PDB|2DY0] (from ''Escherichia coli k12'', 56% identity, 66% similarity)Additional information
[SW|universally conserved protein]Expression and Regulation
Operons
genes
[gene|BA755FA1CB1E0C006E9A23489A7C8997141AA498|recJ]-[gene|38DF74800FC5D54183C58B0EB82BD9A3EB93EE33|apt]
description
[Pubmed|15241682]
regulatory mechanism
[regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]view in new tabReferences
3110131,15241682,22517742