apt [2017-8-11 16:0:3]

adenine phosphoribosyltransferase, universally conserved protein

locus: BSU27610

pI: 4.70

mw: 18.73 kDa

protein length: 170 aa

gene length: 510 bp

function: purine salvage and interconversion

product: adenine phosphoribosyltransferase

essential: no

ec: 2.4.2.7

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.3|Purine salvage and interconversion]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]
• [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]

Gene

Coordinates: 2,822,901 → 2,823,413

The protein

Catalyzed reaction/ biological activity

• AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)

Protein family

• purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)

Modification

• phosphorylated on Arg-85 [Pubmed|22517742]

Structure

• [PDB|2DY0] (from ''Escherichia coli k12'', 56% identity, 66% similarity)

Additional information

• [SW|universally conserved protein]

Expression and Regulation

Operons

• genes: [gene|BA755FA1CB1E0C006E9A23489A7C8997141AA498|recJ]-[gene|38DF74800FC5D54183C58B0EB82BD9A3EB93EE33|apt]
  description: [Pubmed|15241682]

  regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]

  regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

References

• 3110131,15241682,22517742